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Hard Tissue Preparation

Experimental implant research is the implantation of small implants in the bones of animals. The purpose is to examine how a given treatment effects the fixation of an implant. The fixation of an implant can, among others, be illustrated by the use of ”biomechanical push-out test” and ”histomorphometry”. In order to execute these tests, the bones containing the implants have to go through a time-consuming preparation:

The implant bone block is divided in two by means of the Exact bone saw. Half of the block is immediately frozen to -20°C and saved for later use in the "biomechanical push-out test”. The other half is dehydrated in alcohol, colored with basic fusin, and embedded in plastic (polymethylmetacrylate). When embedded, 20-30 µm thin slices are cut off the implant bone block. These slices are used for ”histomorphometric” analysis.

The preparation and cutting of bone containing implants is a technically demanding procedure performed by experienced laboratory technicians at the Orthopaedic Research Lab.

 
Band Saw

Exact Apparatebau
2000 Nordenstadt
Germany

 
Calendar

Publications
The Benefits and Harms of Early Mobilization and Supervised Exercise Therapy after Non-surgically Treated Proximal Humerus or Distal Radius fracture: A systematic Review and Meta-analysis
Østergaard HK, Mechlenburg I, Launonen AP, Vestermark MT, Mattila VM, Ponkilainen VT.
Developing and validating an accelerometer-based algorithm with machine learning to classify physical activity after acquired brain injury.
Honoré H, Gade R, Nielsen JF, Mechlenburg I
Ankle contractures are frequent among children with cerebral palsy and associated with lower gross motor function and degree of spasticity.
Krarup LH, Kristensen PK, Strand L, Bredtoft SL, Mechlenburg I, Nordbye-Nielsen K.
 Orthopaedic Research Aarhus University Hospital Palle Juul-Jensens Boulevard 99 Entrance J 8200 Aarhus N Phone: +45 7846 7471 
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